姓名:云宇
出生年月:1978.05
基本情况:昆明医科大学,基础医学院,教授,博士,博导
行政职务:药理学系主任
社会职务:无
招生专业:药理学
研究领域:高尿酸血症的防治
培养研究生情况:指导硕士生9人,毕业5人,在读4人
电子邮件:yunyu_li@126.com
个人简介:
受教育经历:(按时间倒排序)
2006 /09–2010/07,昆明医科大学,药学院药理系,博士
2003 /09–2006/07,昆明医科大学,基础医学院药理学系,硕士
1996 /09–2001/07,昆明医科大学,临床学院,学士
研究工作经历(按时间倒排序)
2001 /09– 至今,昆明医科大学,基础医学院药理学系,教授
主持或参加科研项目及人才计划项目情况:
1.云南省科技厅科学研究基金,202101AY070001-007,尿酸酶基因敲除大鼠肠道尿酸分布规律及其机制研究,2021.09-2024.10,40万元,在研,主持
2.国家自然科学基金面上项目,81860162,尿酸酶基因敲除模型大鼠的研制,2019.01-2022.12,35万元,在研,主持
3. 云南省教育厅科学研究基金,2018JS153,肠道尿酸的特征性分布及其机制研究,2018.05-2021.05,4万元,已结题,主持
4. 云南省科技厅联合基金,2014FZ006,从肠道毒素入侵途径探讨下肢、腹部受凉导致普通感冒的发病机制,2014.10-2017.09,10万,已结题,主持
5. 云南省科技厅联合基金,2012FB014,缺血后处理对大鼠肾脏再灌注损伤Nrf2/Keap1/ARE通路调节机制的研究,2012.10-2015.09, 10万,已结题,主持
代表性论著(按以下格式填写)
1. 期刊论文:
l Yu Y, Wan X, Li D, Qi Y, Li N, Luo G, Yin H, Wang L, Qin W, Li Y, Li L, Duan W. Dieting alleviates hyperuricemia and organ injuries in uricase-deficient rats via down-regulating cell cycle pathway. PeerJ. 2023;11:e15999.
l Yinfang Gao, Yun Yu, Wan Qin, Nan Fan, Yalin Qi, Huan Chen, Weigang Duan*. Uricase-deficient rats with similarly stable serum uric acid to human’s are sensitive model animals for studying hyperuricemia. PLoS One. 2022;17(3): e0264696
l Nan Fan,Yun Yu, Lvyu Li, Heng Xia, Xiangxian Dong, Yongkun Li, Huan Chen, Weigang Duan*. Uricase deficiency causes mild and multiple organ injuries in rats.PLoS One, 2021; 16(8):e0256594.
l Yun Yu, Nan Zhang, Xianxiang Dong,Nan Fan,Lei Wang,Yuhui Xu, Huan Chen,and Weigang Duan*. Uricase-deficient rat is generated with CRISPR/Cas9 technique,Peer J,8,:e8971 http://doi.org/10.7717/peerj.8971
l Dequan Liu,Yu Yun ,Dechun Yang, Xinyu Hu, Xianxiang Dong, Nan Zhang Hua Yin,Lumei Zhang, Weigang Duan*.what is the biological function of uric acid?An antioxidant for neural protection or a biomarker for cell death,Diseasemarker, 2019:4081962.
l 云宇,李月,杨榕,张路梅,董鲜翔,殷华,熊云霞,段为钢.氨丁三醇在体外促尿酸溶解作用,华西药学杂志,2018,33(1):037-041.
l Yu Yun , Hua Yin , Zhiyi Gao, Yue Li, Tao Gao, Jinlian Duan, Rong Yang, Xianxiang Dong, Lumei Zhang, Weigang Duan*, Intestinal tract is an important organ for lowering serum uric acid in rats,PLoS One, 2017; 12(12):e0190194.
l 云宇,侯肖霖,殷华,柯瑾,段为钢*, 4种去大分子中药注射剂的稳定性研究, 云南中医学院学报,2016,39(04):20~25.
l Yu Yun, Tao Gao, Yue Li, Zhiyi Gao, Jinlian Duan, Hua Yin, Weigang Duan*, Excretory Function of Intestinal Tract Enhanced in Kidney Impaired Rats Caused by Adenine,The Scientific World Journal,2016, 2016: 1~8
2. 会议论文:
l Yu Yun#,Yi Zhang,and Weigang Duan*, Mixed RNA duplexes , a new type of neucleic acid inhibit A549 cell line growing,Proceedings of the 2015 International Conference on, Food Hygiene, Agriculture and Animal Science, 2015, WuHan,P.R. China, 2015.11.18-11.22
l Yu Yun#, Yi Zhang, and Weigang Duan*, Benefits and Disadvantages of Assay Kits in Experimental Education, International Conference on Management Science, Education Technology, Arts, Social Science and Economics, 2015, Qingdao, P.R. China, 2015.11.21-11.25
3. 奖励:云宇,王殿华,褚微微,武步强,朱振东,肾、肝和肠缺血-再灌注损伤及缺血后处理保护机制研究,云南省科技厅, 自然科学奖,三等奖,2012