一、 电子照片
二、简历
1、个人简历
孙乐，女，博士，副教授，硕士生导师，云南省免疫学会中医免疫学分会委员，云南省转化医学学会微创外科分会委员。主持省级科研项目2项，厅级科研项目1项，参与国家自然科学基金项目8项，国家社会科学基金项目1项，参与国家重点研发计划1项，参与云南省重点实验室1项。参与发表SCI论文17篇，其中第一作者论文3篇，获实用新型专利授权1项，获2021年度云南省卫生科技成果奖励三等奖。指导大学生创新性实验项目3项，其中省级1项，校级2项，指导昆明医科大学第十届全国大学生基础医学创新研究暨实验设计论坛大赛校级二等奖一项，获2018-2020年度昆明医科大学“三育人”“教书育人先进个人”，昆明医科大学2024年度第五届全英文课堂教学比赛一等奖。
2、联系方式
电话：13577009479
电子邮箱：sunle@kmmu.edu.cn
通讯地址：昆明市呈贡区春融西路1168号
3、教育经历
2005.09-2008.06 英国伦敦大学皇家霍洛威学院 医学生物化学专业学士
2008.09-2009.09英国克菲尔德大学 分子医学专业硕士
2011.09-2014.07 北京协和医学院 免疫学专业博士
4、工作经历
2009.09-2010.06 英国剑桥文理学院坎特伯雷学院 技术员
2010.09-2011.06中国医学科学院医学生物学研究所 研究实习员
2014.09-2023.10 昆明医科大学 讲师
2023.11-至今 昆明医科大学 副教授
5、承担主要科研项目
1. 云南省科技厅,云南省科技厅昆明医科大学应用基础研究联合专项, 202301AY070001-103,丰宫并殖吸虫ESPs在成虫肺部寄生过程中的潜在作用机制研究, 2023-06至20226-05, 10万元，项目负责人
2. 云南省科技厅,云南省科技厅—昆明医科大学应用基础研究联合专项资金青年博士项目, 2017FE467(- 125),利用CRISPR-Cas9技术对人巨细胞病毒非编码区域定点编辑策略的研究, 2017-07至2021-06, 8万元,项目负责人
3. 云南省教育厅,云南省教育厅科学研究基金项目, 2015Y179,使用CRISPR-Cas9技术对人巨细胞病毒一个miRNA敲除突变株的建立, 2015-10至2017-10, 1万元,项目负责人
6、代表论文、专利和专著
1. Le Sun#; Min Zhu#; Lei Zhang#; Man Peng; Cuiying Li; Liming Wang; Weiqun Wang; Zhiqiang Ma; Shenghao Li; Weilin Zeng; Min Yin; Wenlin Wang; Weixun Chunyu; Differences in microbiome of healthy Sprague Dawley rats with Paragonimus proliferus infection and potential pathogenic role of microbes in paragonimiasis, Acta Tropica, 2022, 233(106578)
2. Bi Yanwei#;Sun Le#; Gao Dandan; Ding Chen; Li Zhihua; Li Yadong; Cun Wei; Li Qihan; High-efficiency targeted editing of large viral genomes by RNA-guided nucleases., PLoS Pathogens, 2014, 10(5): e1004090-e1004090
3. Sun Le#; Li Qihan; The miRNAs of herpes simplex virus (HSV)., Virol Sin, 2012, 27(6): 333-338
4. Yongzhong Duan#;Le Sun; Qihang Li; Herpes Simplex Virus 1 MicroRNAs: An Update, Intervirology, 2023, 66(1): 97-110
5. Yi Wu#; Lei Ran#; Yue Yang; Xianling Gao; Man Peng; Sida Liu;Le Sun; Jia Wan; Yu Yang; Min Yin; Weixun Chunyu; Deferasirox alleviates DSS-induced ulcerative colitis in inhibiting ferroptosis and improving intestinal microbiota, Life Sciences, 2023, 314: 121312.
6. Man Peng#; Liming Wang; Hui Su; Lei Zhang; Yue Yang;Le Sun; Yi Wu; Lei Ran; Sida Liu; Min Yin; Shude Li; Weixun Chunyu; Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats, Journal of Food Biochemistry, 2022, 46(e14321).
7. Cun, Yina; Li, Chuanyin; Shi, Lei; Sun, Ming; Dai, Shuying;Sun, Le; Shi, Li; Yao, Yufeng; COVID-19 coronavirus vaccine T cell epitope prediction analysis based on distributions of HLA c lass I loci (HLA-A, -B, -C) across global populations, Human Vaccines & Immunotherapeutics, 2020.
8. Dai, Shuying; Li, Chuanyin; Yan, Zhiling; Zhou, Ziyun; Wang, Xia; Wang, Jun;Sun, Le; Shi, Li; Yao, Yufeng; Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population, International Journal of Medical Sciences, 2020, 17(7): 931-938.
9. Li Chuanyin; Wang Xiaona; Li Yingfu; Zhang Xinwen; Sun Mingbo; Liu Shuyuan;Sun Le; Shi Li; Yao Yufeng, Genetic polymorphisms in the TERT gene and susceptibility to non-small cell lung cancer in a Chinese Han population, Cancer Management and Research, 2018, 10: 1487-1495
10. Li Chuanyin; Wang Xiaona; Li Yingfu; Zhang Xinwen; Sun Mingbo; Liu Shuyuan;Sun Le; Shi Li; Yao Yufeng, Genetic polymorphisms in the TERT gene and susceptibility to non-small cell lung cancer in a Chinese Han population, Cancer Management and Research, 2018, 10: 1487-1495
11. Zhihua Li; Yanwei Bi; Hongjian Xiao; Le Sun; Yuan Ren; Yadong Li; Chen Chen; Wei Cun,CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes,Virus Research,2018, 244: 286-295
12. Weilin Zeng#; Ling Sun#; Zheng Xiang#; Na Li; Jie Zhang; Yongshu He; Qing Li; Fang Yang; Jingling Song; James Morris; Benjamin M. Rosenthal;Le Sun; Huaie Liu; Zhaoqing Yang*, Morphological and molecular characteristics of Sarcocystis bertrami from horses and donkeys in China, Veterinary Parasitology,2018,252:89-94
13. Li, Rongcheng#; Liu, Longding#; Mo, Zhaojun#; Wang, Xuanyi#; Xia, Jielai; Liang, Zhenglun; Zhang, Ying; Li, Yanping; Mao, Qunying; Wang, Jingjing; Jiang, Li; Dong, Chenghong; Che, Yanchun; Huang, Teng; Jiang, Zhiwei; Xie, Zhongping; Wang, Lichun; Liao, Yun; Liang, Yan; Nong, Yi; Liu, Jiansheng; Zhao, Hongling; Na, Ruixiong; Guo, Lei; Pu, Jing; Yang, Erxia;Sun, Le; Cui, Pingfang; Shi, Haijing; Wang, Junzhi; Li, Qihan; An inactivated enterovirus 71 vaccine in healthy children., N Engl J Med, 2014, 370(9): 829-837
14. Yue, Lei, Guo Sujie, Cao Xia, Zhang Ying, Sun Le, Liu Longding, Yan Min, Li Qihan, PNKP knockdown by RNA interference inhibits herpes simplex virus-1 replication in astrocytes, Virol Sin, 2013, 28(6): 345-351
15. Yue Lei, Guo Sujie, Zhang Ying, Liu Longding, Wang Qingling, Wang Xi, Shen Dong, Wang Lichun, Sun Le, Wang Jingjing, Liao Yun, Li Qihan, The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes, PLos One, 2013, 8(11): e79648-e79648
16. Musa Maslinda, Wilson Kirsty, Sun Le, Mulay Apoorva, Bingle Lynne, Marriott Helen M, LeClair Elizabeth E, Bingle Colin D, Differentia l localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice, Cell and Tissue Research, 2012, 350(3): 455-464
17. Yang Erxia, Zhao Heng, Zhang Ying, Liu Jiansheng, Liao Yun, Wang Lichun, Cui Pingfang,Yang Lixian, Liu Longding, Dong Chenghong, Dong Shaozhong, Shao Congwen, Jiang Li, Sun Le, Li Qihan, A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B), Science China Life Sciences, 2012, 55(4): 336-342
18. 孙乐;黄泓泰;李佳怿;彭漫;王谦;张磊;一种巨细胞病毒一体化核酸检测装置, 2021-8-20,中 国, ZL202022310887.8
7、获得奖励
1. 宿主免疫相关基因及HPV变异与宫颈癌发生发展的相关性和诊断价值，云南省卫生科技成果奖三等奖，严志凌，戴书颖，李传印，杨宏英，刘舒媛，张芍，张新文，杨佳，孙乐，许金美，2021年。
